Alzheimer’s Linked to Loss of Y Chromosome in Men

Y chromosome loss

01 Jun Alzheimer’s Linked to Loss of Y Chromosome in Men

Research has shown that loss of Y chromosome in men can increase cancer risks.  Now the research shows it may also increase Alzheimer’s risk.  Thank you for visiting Veteran Care.  We help senior Veterans every day access available benefits. VeteranCare is dedicated solely to assisting veterans and their spouses with their healthcare needs. Contact us today! 

New research, presented this week at the European Society of Human Genetics conference in Barcelona, Spain, demonstrates that men whose blood cells lack Y chromosomes are more susceptible to Alzheimer’s disease. The team hopes that, in the future, these findings might help develop an early warning system for Alzheimer’s.

Alzheimer’s disease affects more than 5 million Americans; that equates to 1 in 9 people over the age of 65.

By 2050, the number of individuals with the condition is predicted to rise to 14 million.

Despite the huge number of Alzheimer’s cases, the molecular mechanisms behind it and the exact risk factors are still poorly understood.

The primary risk factor for Alzheimer’s disease is advanced age, but there do seem to be other parameters involved.

For instance, there appears to be a genetic susceptibility. Other researchers have investigated links between Alzheimer’s and high blood pressure, low folate intake, and high cholesterol levels; levels of mental and physical activity are also thought to play a role.

Recent research, examining an unusual but prevalent genetic change in men, may have unearthed a new clue to the etiology of Alzheimer’s.

Loss of Y chromosome

Females have two X chromosomes, while men have one X and one Y. Among other things, the Y chromosome contains code that triggers the development of the testis.

Over recent years, it has been noted that in some men, the Y chromosome slowly degenerates as they age. This is referred to as loss of Y (LOY).

Studies looking at the effects of this age-related decay of the Y chromosome have tentatively linked it with certain cancers. Some researchers believe that, in the future, LOY measurement may act as an early warning system for individuals who are particularly susceptible to some cancers.

Men are known to live shorter lives than women and are more likely to develop non-sex-specific cancers. Some scientists believe that the loss of the Y chromosome could help explain this gender difference.

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